Fluoroquinolones (and related)

Key points


Beneficial actions and effects

Fluroquinolone antibiotics inhibit binding of DNA gyrase(aka topoisomerase II) to specific portions of DNA (the ligase domain). This prevents uncoiling of bacterial DNA required for duplication. Continued activity of topoisomerase II (other regions of DNA) leads to DNA fragmentation and cell death.

Antibacterial activity
Resistance (by bacteria)

Adverse effects

A spectrum of adverse effects but relatively consistent between species


Fluoroquinolones are relatively uniform (consistent across the individual drugs)

Veterinary drugs

USP/AAVPT Monograph for Fluoroquinone(s)